Animal Models of Drug Addiction by Styliani Vlachou, Athina Markou (auth.), Mary C. Olmstead

By Styliani Vlachou, Athina Markou (auth.), Mary C. Olmstead (eds.)

Our knowing of dependancy and the way it really is handled has complicated remarkably during the last many years, and lots more and plenty of the development is said on to animal learn. this is often real for either the behavioural elements of drug use in addition to the organic underpinnings of the disease. In Animal types of Drug habit, specialists within the box offer an updated evaluate of advanced behavioural paradigms that version varied phases of this affliction and clarify how each one try is used to successfully reflect the development of drug habit. This certain and sensible ebook starts with the commonest laboratory measures of habit in animals, together with intracranial self-stimulation (ICSS), drug self-administration, position conditioning, and sensitization. Later chapters describe how those paradigms are used to version the development of drug dependancy, delivering perception into the scientific symptomatology of habit from acquisition of drug use via compulsive drug taking to withdrawal and relapse. Written for the preferred Neuromethods sequence, the contributions provide either methodological element and a theoretical standpoint, attractive to readers conversant in preclinical examine on drug habit in addition to people who are novices to the sphere. state-of-the-art and authoritative, Animal types of Drug habit will function a foundation for destiny important study that hyperlinks the bench to the bedside within the an important remedy of drug addiction.

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Our realizing of dependancy and the way it truly is taken care of has complicated remarkably over the last a long time, and lots more and plenty of the growth is expounded on to animal study. this is often precise for either the behavioural points of drug use in addition to the organic underpinnings of the affliction. In Animal types of Drug habit, specialists within the box supply an updated evaluate of complicated behavioural paradigms that version varied phases of this affliction and clarify how each one try out is used to successfully reflect the development of drug habit.

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Accordingly, administration of the mGluR2/3 antagonist LY341495 attenuated threshold elevations in rats undergoing spontaneous nicotine ­withdrawal (217). Altogether, these findings suggest that chronic exposure to nicotine decreases cholinergic, dopaminergic, and glutamatergic transmission to mediate the affective aspects of nicotine withdrawal once nicotine administration is discontinued. Recent studies have also implicated hyperactivitiy in the corticotropin-releasing factor (CRF) system in the anhedonic aspects of nicotine withdrawal.

3), an effect that is dose-dependent (114, 178, 181, 186, 187). The time-, dose-, and procedure-dependency of the effects of nicotine were demonstrated in studies by Clarke and Kumar (177) and Schaefer and Michael (178). , movements between photobeams) in rats permitted to turn on and off electrical stimulation by running along opposite walls of a shuttle box (177). However, this effect was only observed in the first few minutes after the nicotine injection. , increased movements between photobeams) even when the stimulation was not available (177).

5 mg/kg D9-THC lowered thresholds in Lewis rats (251, 254). In the rate-frequency curve-shift procedure, the most pronounced action of D9-THC was found after administration of 1 mg/kg in Lewis rats compared with Sprague-Dawley or Fisher rats. These differences in effects in various rat stains may be attributable to Lewis rats being more sensitive and vulnerable to the effects of addictive drugs than other strains (252), suggesting an important genetic component in the actions of cannabinoids. Notably, the reward-facilitating effects of D9-THC in the aforementioned studies are much less pronounced than those of other drugs of abuse, such as morphine, cocaine, amphetamine, or nicotine.

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