By Perry J. Pickhardt MD, David H. Kim MD
In CT Colonography, Perry Pickhardt and David Kim current strategies for faster evaluate and prognosis of colon melanoma during the pioneering, specialty-changing imaging means of digital colonoscopy (VC). this mix of refined X-rays and CT scans of the stomach deals sufferers an alternative choice to colonoscopy that's in your price range and decreases the necessity for pointless polyp elimination. Abundantly illustrated in complete colour, this pioneering publication describes CT colonography from pathogenesis, staging and remedy via symptoms, procedure, and interpretation for the commonest pathologies. you should have the entire spectrum of VC strategy and manage to see methods played via videos at the integrated DVD.Covers ideas, recommendations, and interpretations for the most typical pathologies in a logical, sensible organization.Presents information from the authors on constructing a VC perform to supply a private, instructive guide.Provides over one thousand full-color, high-resolution anatomic photographs all through for the clearest, such a lot exact photo of colorectal melanoma, its typical heritage, and its prognosis via VC.Focuses on pictures, with the textual content serving as context for the correct use and realizing of VC.Features a DVD with videos of VC methods that make clear the textual content and complement the photographs which are integrated for obtain.
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Additional resources for CT Colonography: Principles and Practice of Virtual Colonoscopy
Senescence and serration: A new twist to an old tale. J Pathol. 2006;210(2):137-140. 28. Jass JR, Iino H, Ruszkiewicz A, et al. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut. 2000;47(1):43-49. 29. Thibodeau SN, French AJ, Cunningham JM, et al. Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLH1. Cancer Res. 1998;58(8): 1713-1718. 30. Jass JR, Baker K, Zlobec I, et al. Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: Concept of a “fusion” pathway to colorectal cancer.
Konishi F, Morson BC. Pathology of colorectal adenomas—A colonoscopic survey. J Clin Pathol. 1982;35(8):830-841. 6. Obrien MJ, Winawer SJ, Zauber AG, et al. The National Polyp Study—Patient and polyp characteristics associated with highgrade dysplasia in colorectal adenomas. Gastroenterology. 1990; 98(2):371-379. ever, specific elements within the diet or environment as a modifier of risk are difficult to ascertain. Epidemiologic observational studies often have many confounding variables, and prospective prevention clinical trials often alter associated behaviors in addition to the primary dietary intervention.
The molecular pathway of the adenoma–carcinoma sequence is termed the “suppressor” or “chromosomal instability” pathway and is characterized by loss or inactivation of large portions of chromosomes, whereas the serrated polyp–carcinoma sequence is termed the “mutator” pathway and is largely characterized by microsatellite instability where there are variations in areas of small microsatellite repeats within the chromosome as a result of uncorrected replication errors. A second minor pathway within the serrated polyp–carcinoma sequence is characterized by low microsatellite instability (MSI-low) cancers.