CURED I - LENT Late Effects of Cancer Treatment on Normal by Philip Rubin, L.S. Constine, Lawrence B. Marks, Paul

By Philip Rubin, L.S. Constine, Lawrence B. Marks, Paul Okunieff

The look for the main favorable healing ratio – at which ablation of melanoma is accomplished whereas general tissues are conserved – has been smooth radiation oncology’s identical of the search for the Holy Grail. Our expertise of the overdue results of radiation grew prior to now century as new modalities have been brought. Heightened common tissue reactions followed the better premiums of melanoma ablation completed through escalation of radiation doses, sped up fractionated radiotherapy, and competitive concurrent chemotherapy and radiation regimens. This quantity relies at the LENT V NCI-sponsored assembly held in could 2004 and the CURED I convention held in 2006. Written by means of specialists within the box, it addresses a couple of serious subject matters in terms of overdue results, comparable to mechanisms of harm, the function of screening, suggestions for interventions, moment malignancies, and prevention. it's was hoping that it'll support the reader in figuring out the best way to hinder and deal with the long term side-effects of irradiation.

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In: Rubin DB (ed) The radiation biology of the vascular endothelium. CRC Press, Boca Raton, pp 185–208 14. Fajardo LF (1998) The endothelial cell is a unique target of radiation: an overview. In: Rubin DB (ed) The radiation biology of the vascular endothelium. CRC Press, Boca Raton, pp 1–12 15. Murray JC (1998) Inflammatory cytokines, radiation and endothelial gene products: a common role for reactive oxygen intermediates. In: Rubin DB (ed) The radiation biology of the vascular endothelium. CRC Press, Boca Raton, pp 147–160 16.

Radiat Res 136:15–21 15. Vit JP, Rosselli F (2003) Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis. Oncogene 22:8645–8652 16. Kolesnick R, Fuks Z (2003) Radiation and ceramide-induced apoptosis. Oncogene 22:5897–5906 17. Gross NJ (1981) The pathogenesis of radiation-induced lung damage. Lung 159:115–125 18. Hallahan DE, Spriggs DR, Beckett MA et al (1989) Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci USA 86:10104–10107 19.

Indeed, upregulation of NF-NB, as well as the early response genes, namely c-abl, c-fos, c-jun, and egr-1, activate the cells to produce cytokines that amplify the inflammatory process [1–3, 7]. Specifically, we have shown that NF-NB can be activated via reactive oxygen species generated from radiation. This process leads to the induction of a pro-inflammatory cascade including TNFD [18, 19]. In addition, it has become well known that growth factors are also released, particularly TGF-E. TGF-E has been implicated in the actual lung fibrosis that occurs following radiation insult.

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