CURED I - LENT Late Effects of Cancer Treatment on Normal by Philip Rubin, L.S. Constine, Lawrence B. Marks, Paul

By Philip Rubin, L.S. Constine, Lawrence B. Marks, Paul Okunieff

This quantity relies at the LENT V NCI-sponsored assembly held in may perhaps 2004 and the CURED I convention in 2006. Written via specialists within the box, it addresses a severe themes on the subject of past due results, similar to mechanisms of damage, the position of screening, strategies for interventions, moment malignancies, and prevention. it really is was hoping that those findings may help readers to avoid and deal with the long term side-effects of irradiation.

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Vascular tone regulation: Through angiotensin converting enzyme and endothelin, EC contract smooth muscle while nitric oxide relaxes it. ¼ Angiogenesis: This, the formation of microvessels in the fully developed vertebrate, is the most dynamic function of the endothelium; it occurs in response to a large number of agonists and antagonists. , in neoplasia and many inflammatory diseases) [4, 5]. The above, and other endothelial cell functions, are regulated by numerous genes, many of which have been characterized [6].

Semin Radiat Oncol 12:1–111 15. Penz M, Kornek GV, Raderer M et al (2001) Subcutaneous administration of amifostine: a promising therapeutic option in patients with oxaliplatin-related peripheral sensitive neuropathy. Ann Oncol 12:421–422 16. Koukourakis MI, Simopoulos C, Minopoulos G et al (2003) Amifostine before chemotherapy: improved tolerance profi le of the subcutaneous over the intravenous route. Clin Cancer Res 9:3288–3293 17. Cassatt DR, Fazenbaker CA, Kifle G et al (2003) Subcutaneous administration of amifostine (ethyol) is equivalent to intravenous administration in a rat mucositis model.

Collagens, laminin, thrombospondin, fibronectin L. Fajardo Fig. 1. A normal endothelial cell attached to its basal lamina (bottom), which is partially denuded on the right. The main functions described here are indicated in bold uppercase letters, with examples in lowercase. ABO, blood antigens; ACE, angiotensin converting enzyme; GM-CSF, granulocyte-monocyte colony stimulating factor; LDL, low density lipoproteins; MHC I & II, major histocompatibility complexes; NO, nitric oxide; PGI2 , prostacyclin.

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