Current Understanding and Treatment of Gliomas by Jeffrey Raizer, Andrew Parsa

By Jeffrey Raizer, Andrew Parsa

This booklet stories the numerous advances in our realizing of glioma biology which have been completed in past times decade and describes intimately the ensuing new ways to remedy. advancements in surgical innovations, radiation remedy, and chemotherapy are comprehensively lined, with dialogue in their influence in reducing sufferer morbidity and lengthening survival. additionally, person chapters are dedicated particularly to present therapy for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. different themes addressed contain remedy of the aged sufferer, investigating rising treatments from small molecules to immunotherapy and palliative care. This well timed booklet could be a precious resource of updated details for practitioners and also will be of curiosity to researchers.

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Neurology 75(17):1560–1566. 0b013e3181f96282 29. Humphrey PA, Wong AJ, Vogelstein B, Zalutsky MR, Fuller GN, Archer GE, Friedman HS, Kwatra MM, Bigner SH, Bigner DD (1990) Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. Proc Natl Acad Sci USA 87(11):4207–4211 30. Jiang H, Ren X, Cui X, Wang J, Jia W, Zhou Z, Lin S (2013) 1p/19q codeletion and IDH1/2 mutation identified a subtype of anaplastic oligoastrocytomas with prognosis as favorable as anaplastic oligodendrogliomas.

The SLF connects the parietal/temporal region with the frontal lobe and is composed of two functionally distinct white matter pathways—the arcuate fasciculus (AF) and an indirect pathway parallel and lateral to the AF termed the lateral SLF (latSLF). The AF (also termed the dorsal phonologic stream) connects the posterior middle and inferior frontal gyri with the posterior portion of the middle and inferior temporal gyri, with interruption at any site along the pathway resulting in phonological disturbances.

L. Cohen and H. Colman 87. Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutaratedependent dioxygenases. Cancer Cell 19(1):17–30. 014 88. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD (2009) IDH1 and IDH2 mutations in gliomas.

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